Basis

Basis

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NAD+ Supplement for Cellular Aging

Target aging at the source—your cells. Increase your NAD+ levels with Basis for healthy aging, to boost cellular energy, and maintain healthy DNA. Developed by Elysium chief scientist and renowned aging researcher Leonard Guarente, Ph.D. Increase and sustain NAD+ levels by 40% to:

  • Promote healthy aging, feel good for your age
  • Promote cellular energy and reduce general tiredness and fatigue
  • Fight aging at the cellular level and protect your DNA from stressors
  • Support collagen and ceramide synthesis for healthy skin
  • Support healthy muscle function

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Basis

Basis

$45.00
$45.00 $50.00
SAVE 10% Sold out

Ingredients

Basis contains two powerful ingredients to combat cellular aging:

  • Nicotinamide Riboside Chloride (NR)

    NR is a naturally occurring form of vitamin B3 and a highly efficient precursor to NAD+—the raw material that the body uses to make NAD+ via a two-step process. This precursor has been shown to preferentially elevate NAD+ compared to nicotinic acid and nicotinamide, also called niacin.
  • Pterostilbene (PT)

    A powerful polyphenol naturally produced by plants to protect against internal and external stress. The potent combination of NR and pterostilbene in Basis is designed to increase NAD+ levels and counter the decrease in the activity of sirtuins, which occurs with normal aging.
  • Vegetarian, vegan, gluten-free, nut-free, and contains no artificial colors or flavors.
  • NSF Certified for Sport, the only independent third-party certification program recognized by the United States Anti-Doping Agency (USADA). Please confirm the certification of each lot here.
  • See nutrition label for more information.
  • The quality and purity information of every lot is available here.

Recommended Use

  • Take two capsules in the morning, with or without food.
  • Each pouch contains a 30-day supply.
  • This product is only intended for healthy adults. Do not take if you are pregnant or nursing. Consult with your physician before using.
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DESCRIPTION

Target aging at the source—your cells. Increase your NAD+ levels with Basis for healthy aging, to boost cellular energy, and maintain healthy DNA. Developed by Elysium chief scientist and renowned aging researcher Leonard Guarente, Ph.D. Increase and sustain NAD+ levels by 40% to:

  • Promote healthy aging, feel good for your age
  • Promote cellular energy and reduce general tiredness and fatigue
  • Fight aging at the cellular level and protect your DNA from stressors
  • Support collagen and ceramide synthesis for healthy skin
  • Support healthy muscle function

NAD+ Levels and
Healthy Aging
go Hand-in-Hand

Research published in Nature Aging “suggests that a clear association exists between NAD+ and health status in human aging.” NAD+ (nicotinamide adenine dinucleotide) is found in every cell in your body. It is essential to the chemistry that keeps you up and running.

Unfortunately, NAD+ levels decline universally as we age.

How can you increase your NAD+ levels? Basis is the evidence-based choice

We now have a way to safely and sustainably boost NAD+ levels. Developed by Dr. Leonard Guarente, a leader in the field of aging research, Basis was clinically proven to increase NAD+ levels by an average of 40% in a double-blind, randomized, placebo-controlled clinical trial published in the peer-reviewed journal Nature Partner Journals: Aging and Mechanisms of Disease. 

Boosted NAD+ activates sirtuins, supports cellular energy and metabolism, targets cellular aging to promote a healthy cellular aging process, and helps maintain healthy DNA.

"Given the momentum in human studies targeting aging, we are optimistic that the course of human health could be fundamentally changed."

Leonard Guarente, Ph.D.

Elysium co-founder & chief scientist

WHO IS BASIS FOR?

01｜PEOPLE FOCUSED ON HEALTHY AGING

As we age, NAD+ levels naturally decline. Basis is designed to support healthy aging at the cellular level, making it suitable for adults who want to take a proactive approach to long-term health and support healthy function as they age.

02｜PEOPLE LOOKING TO MAINTAIN DAILY ENERGY & VITALITY

NAD+ plays an important role in cellular energy processes. Basis is designed to support cellular energy and help maintain everyday vitality, making it a fit for healthy adults with busy schedules who want to support their daily energy levels.

03｜PEOPLE WHO PRIORITIZE CELLULAR HEALTH & LONG-TERM WELL-BEING

For those looking beyond how they feel today and focusing on long-term cellular health, Basis offers a targeted approach. Its key ingredients, NR and pterostilbene, are formulated to support NAD+ levels and cellular health.

04｜PEOPLE FOCUSED ON SKIN & PHYSICAL FUNCTION

NAD+ is involved in processes related to collagen and ceramide production, while Basis is also designed to support healthy muscle function. It may appeal to adults who care about maintaining healthy skin, skin barrier function, and physical performance as they age.

05｜MIDDLE-AGED & MATURE ADULTS WITH A LONG-TERM HEALTH MINDSET

Basis has been studied in healthy adults aged 60–80, with research showing an average increase of approximately 40% in NAD+ levels. For marketing purposes, it can be positioned for adults who are becoming more proactive about aging, daily vitality, and long-term health—without making claims about treating or reversing aging.

“I believe Basis is a product that can improve cellular health and target, at least, some of the deficits incurred by aging. It is an important part of a strategy that I follow, along with exercise and a healthy diet, to maintain an active life as I enter my seventies, and hopefully much longer.”“I believe Basis is a product that can improve cellular health and target, at least, some of the deficits incurred by aging. It is an important part of a strategy that I follow, along with exercise and a healthy diet, to maintain an active life as I enter my seventies, and hopefully much longer.”

Leonard Guarente, Ph.D.,Elysium Co-founder and Chief Scientist

Why is Basis
unique among
NAD+ supplements?

Basis is clinically proven to safely and sustainably increase NAD+ by an average of 40% in humans. Elysium’s toxicology study also confirmed the superiority of the NR-E in Basis when compared to the published safety profiles of other NAD+ supplements, underscoring the company’s rigorous commitment to research and quality. 

The synergistic combination of Elysium’s proprietary and high-purity nicotinamide riboside (NR-E) with potent antioxidant pterostilbene (PT) makes Basis extraordinarily effective. Basis is also third-party tested by independent labs both during and after manufacture for purity and quality, and is independently verified as NSF Certified for Sport.

Basis Journey

Day 30
Day 60
Day 180
Day 365

Hour 4

You just took Basis—nothing could be happening yet, right? Actually, the nicotinamide riboside is already making big moves. It enters your cells via equilibrative nucleoside transporters, membrane proteins that shuttle molecules across.

Day 01

NAD+ levels are already on the rise at the cellular level. You can expect support for increased cellular energy, improved mitochondrial function, housekeeping for your proteome and genome, and cellular protection from everyday stressors (for example, oxidative stress). Not bad for a day's work.

Day 14

NAD+ levels continue to rise in your cells and throughout your body. Keep doing what you're doing while Basis works in the background to sustain your cellular health.

Day 30

Now results are really adding up. If you had all the gear for NAD+ analysis from whole-blood lysate, you could see for yourself. Your cellular NAD+ levels are now 40% higher than they were on day one, and that's where they'll stay if you keep taking Basis. Where is all this NAD+ going? Studies suggest that NR supplementation increases NAD+ and affects NAD+-related metabolites in multiple tissues at 30 days—including your muscle and brain.

Day 60

You've logged 30 days of elevated and sustained NAD+ levels in your cells and tissues. That's a big deal because 330 billion cells turn over each day. Colon epithelial cells, for example, turn over in 3-5 days while the epidermis takes roughly 39 days to regenerate. NAD+ can help with supporting these processes and tissue health.

Day 180

A lot happens in six months. What's changed in your life? With Basis, it's all starting to add up—to systemic health benefits. Basis is supporting multiple tissues and systems, in a sustained manner. For example, one study showed that six months of increased NAD+ levels reduced transepidermal water loss—a measure of overall skin health and barrier function.

Day 365

Congratulations on your first year. NAD+ declines by as much as 50% every 20 years, according to research. But human studies are beginning to show an association between NAD+ abundance and healthy aging status. Keep taking Basis to counteract the age-related decline of NAD+ and to build on a year's worth of benefits. Just like with exercise, sleep, and diet—consistency is key.

Basis 101: The Science

  • What is NAD+ and why is it important?

    NAD+ (nicotinamide adenine dinucleotide) is a coenzyme found in every living cell, where it helps turn food into cellular energy and supports hundreds of metabolic reactions. Your body makes NAD+ from precursors in your diet, but levels fall as you age.

    That decline is why NAD+ has become one of the most studied molecules in aging research, and why NAD+ supplements built around precursors like NR and NMN draw so much interest.

  • What is nicotinamide riboside?

    Nicotinamide riboside (NR) is a form of Vitamin B3 and a precursor to nicotinamide adenine dinucleotide (NAD+), a coenzyme vital to cellular health.

    NR is found in small amounts in foods like dairy products and is one of several variations of Vitamin B3.

    NR supplementation is clinically proven to increase NAD+ levels and provide benefits for promoting cellular energy and healthy aging.

  • What is pterostilbene?

    Pterostilbene is a powerful antioxidant found in certain berries and nuts that is similar to resveratrol but more potent.

    Pterostilbene has a slightly different structure that makes it more bioavailable than resveratrol.

    Pterostilbene is a potent activator of SIRT1, an NAD(+)-dependent enzyme that plays a critical role in cellular health and DNA maintenance.

    • 25+

      Internationally 
      Renowned Scientific 
      Advisors

    • NSF

      certified for sport
      + 3rd-Party Tested
      for Purity & Quality

    • 16+

      Ongoing + 
      Completed Human 
      Clinical Trials

    • OXFORD 
      + YALE

      tier-1 research collaborations and partnerships

      RECOMMENDED USE

      • Take two capsules in the morning, with or without food.
      • Each pouch contains a 30-day supply.
      • This product is only intended for healthy adults. Do not take if you are pregnant or nursing. Consult with your physician before using.

      Our Team

      The Elysium team is made up of individuals who are passionate about creating a fundamentally new approach to healthcare, one that focuses not exclusively on disease but on health.

      We tackle challenges with creativity, integrity, and a willingness to collaborate. We believe that aging is not only the greatest risk factor for all major chronic conditions, but that aging research represents the most significant opportunity to improve human health today. It is our responsibility to share the benefits of aging research with as many people as possible, to effect real and meaningful change. This includes our colleagues, our families, and our friends—who were the original inspiration for Elysium.

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      Frequently Asked Questions

      Sirtuins are a family of proteins that regulate cellular health. Sirtuins play a key role in regulating cellular homeostasis. Homeostasis involves keeping the cell in balance. However, sirtuins can only function in the presence of NAD+, nicotinamide adenine dinucleotide, a coenzyme found in all living cells.

      NAD+, or nicotinamide adenine dinucleotide, is a critical coenzyme found in every cell in your body, and it's involved in hundreds of metabolic processes — but NAD+ levels decline with age. NAD+ has two general sets of reactions in the human body: Helping turn nutrients into cellular energy as a key player in metabolism and working as a helper molecule for proteins that regulate other cellular functions.

      This form of Vitamin B could be the key to increasing NAD+ levels — here's why. Nicotinamide riboside is often called NR for short, and it's a precursor to NAD+, meaning it's the raw material from which your body makes NAD+ through a series of chemical transformations.

      Pterostilbene is a polyphenol, a type of molecule that occurs in plants, particularly small berries and nuts. Blueberries are a particularly rich source of pterostilbene; although it is found in grapes, pterostilbene doesn't survive the wine-making process.